Testenate Depot 250 (Testosterone Enanthate)- 8

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Testenate Depot 250 is a medication that contains testosterone enanthate. It is a synthetic form of the male hormone testosterone. This injection is used in hormone replacement therapy for men with conditions such as hypogonadism (low testosterone levels) or delayed puberty. It works by increasing the levels of testosterone in the body. 

How does it Work?

Testenate Depot 250 contains the active ingredient Testosterone Enanthate. It works by replacing or supplementing endogenous testosterone. It is a primary male sex hormone responsible for the development and maintenance of male sexual characteristics. This solution is slowly released into the bloodstream after intramuscular injection. It provides sustained testosterone levels over time.

Uses

Hypogonadism: A condition characterized by inadequate testosterone production.

Recommended Dose

Testenate Depot 250 is typically administered by intramuscular injection at regular intervals. It is injected into the gluteal muscle once every 1 to 4 weeks.  Follow your doctor’s exact instructions.

Missed Dose

If you miss a dose, take it as soon as you remember. However, if it is time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

Overdose

Taking more than the recommended amount can lead to an overdose and cause adverse side effects. In cases of overdose, seek emergency medical attention immediately. 

Side Effects

The most common side effects include:

  • acne
  • pain at the site
  • mood changes
  • increased aggression
  • headaches

Rare but Serious Side Effects:

  • infertility
  • polycythemia
  • cardiovascular risks
  • liver toxicity
  • fluid retention
  • testicular atrophy
  • decreased sperm production
  • increased red blood cell count
  • increased risk of blood clots
  • enlarged prostate
  • difficulty urinating
  • increased risk of prostate cancer
  • gynecomastia (breast enlargement)
  • anxiety
  • depression
  • fatigue
  • insomnia
  • hair loss
  • increased body hair growth
  • oily skin
  • acne
  • skin irritation

If you experience any severe, persistent, or concerning side effects, seek immediate medical attention.

Safety Advice

Testenate Depot 250 solution should be used with caution and under medical supervision. Follow your doctor’s instructions carefully and report any adverse effects promptly. Here are some safety precautions to keep in mind:

  • Do not use this injection if you are allergic to testosterone enanthate. 
  • This solution should only be taken under medical supervision and as prescribed by your doctor. Do not adjust the dose or use it for bodybuilding/enhancing athletic performance.
  • Let your doctor know if you have heart disease risk factors.
  • It may cause fertility issues and shrinkage of the testicles in males. Use contraception during treatment if trying to avoid pregnancy.
  • Inform your doctor if you have sleep apnea, prostate cancer, heart failure, and liver disease. Discuss your medical history.
  • It is not approved for use in women. Testosterone enanthate can cause virilizing side effects like male pattern baldness and voice changes.
  • This drug is not recommended for use in men with breast or prostate cancers.
  • Follow injection site rotation instructions carefully. This is to prevent infection or site reactions when using injectable forms.

Medical Interactions

Certain medications may interact with Testenate Depot and alter its effectiveness or increase the risk of side effects. Inform your doctor about all the medications you are taking to avoid potential interactions. This includes prescription drugs, over-the-counter medications, vitamins, and herbal supplements. 

Some significant drug interactions include:

  • Warfarin
  • Insulin
  • Oral antidiabetic medications
  • Corticosteroids
  • Anticonvulsants (e.g., phenytoin, carbamazepine)
  • St. John’s wort
  • HIV protease inhibitors (e.g., ritonavir)
  • Hepatitis C antiviral agents (e.g., telaprevir)
  • Azole antifungals (e.g., ketoconazole, itraconazole)

This is not an exhaustive list. Consult your doctor or pharmacist about potential drug interactions before taking this drug.

Storage

Follow these storage guidelines to keep the tablets effective and intact for a longer time-

  • Store the tablets at room temperature.
  • Keep the medication in its original packaging tightly closed.
  • Protect from light, moisture, and excessive heat.
  • Do not store in the bathroom or near a sink, as the moisture and heat can degrade the medication.
  • Keep out of reach of children and pets.
  • Do not use the medication after the expiration date printed on the package or container.
  • Discard any unused or expired medication properly. Follow local regulations for the disposal of medications.

Refrences

  1. Rogerson S, Weatherby RP, Deakin GB, Meir RA, Coutts RA, Zhou S, Marshall-Gradisnik SM. The effect of short-term use of testosterone enanthate on muscular strength and power in healthy young men. J Strength Cond Res. 2007 May;21(2):354-61. https://pubmed.ncbi.nlm.nih.gov/17530941/ 
  2. Mayo Clinic. Testosterone. https://www.mayoclinic.org/healthy-lifestyle/sexual-health/in-depth/testosterone-therapy/art-20045728 
  3. Drugs.com. Testosterone. https://www.drugs.com/pregnancy/testosterone.html 

Central Drugs Standard Control Organisation (CDSCO). https://cdscoonline.gov.in/CDSCO/Drugs

Frequently asked questions (FAQs) about ED medication

  1. How long does it take for Testenate Depot 250 mg to work?

    Testenate Depot 250 mg starts to work shortly after administration. However, it may take several (3-4) weeks to months for noticeable improvements in symptoms of low testosterone. Continuous treatment is necessary to maintain testosterone levels within the normal range.

  2. Can Testenate Depot 250 mg be used for bodybuilding or athletic performance enhancement?

    Testenate Depot 250 mg is sometimes misused for non-medical purposes, such as bodybuilding or athletic performance enhancement. However, such use is illegal and poses serious health risks.

  3. Who should not take Testenate Depot 250 mg?

    People with breast cancer, prostate cancer, and kidney disease should not take Testenate Depot 250 mg.

  4. Can Testenate Depot 250 mg be used by women?

    Testenate Depot 250 mg is not typically recommended for use in women. It can cause masculinizing effects such as deepening of the voice, enlargement of the clitoris, and growth of facial and body hair.

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