Penegra 100 mg

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Penegra 100mg is used primarily to treat men who have erectile dysfunction (also called impotence). The medication is taken orally. It contains sildenafil as its main active ingredient. It is a powerful PDE5 inhibitor. It works by improving blood flow into the penis, thereby activating a firm erection. This may lower stress and anxiety associated with intercourse and help men regain confidence in the bedroom. 100 mg of sildenafil is one of the highest possible doses for erectile dysfunctions. Take Penegra 100mg as directed by a doctor.

How does it Work?

Penegra 100mg contains the active ingredient sildenafil. It belongs to a group of medicines PDE5 inhibitors.

During sexual arousal, a molecule called nitric oxide (NO) is released within the penis. This increases levels of another molecule called the cGMP. cGMP causes the smooth muscles inside the penis to relax.

As a result, the blood vessels open wider allowing for blood to flow. It causes the corpus cavernosa (the spongy tissue in the penis) to swell. Thus, the penis becomes larger and stiff enough for sexual intercourse.

However, an enzyme called PDE5 breaks down cGMP molecules, ending the erection. PDE5 inhibitors such as sildenafil stop PDE5 from working too quickly. It prevents the cGMP breakdown. Hence, the action of nitric oxide is enhanced, promoting blood flow. This helps prolong the erection, making it firm enough for intercourse.

Note that Penegra 100mg itself directly does not cause an erection. It helps the body respond better to sexual arousal. Sildenafil has no effect where sexual stimulation is absent.

Uses

Erectile Dysfunction (ED):

Difficulty getting or keeping an erection firm enough to have sex. The condition is also known as ‘impotence’. It prevents some men from having a pleasant sexual performance.

Pulmonary Arterial Hypertension (PAH):

A type of high blood pressure in the arteries that carry blood to the lungs.

Recommended Dose

For ED, take a Penegra 100mg tablet about 1 hour before sex. The whole tablet is swallowed with water. Do not take more than the recommended dose in 24 hours.

For first time users, a lower dose of sildenafil may be prescribed. This can minimize the risk of unpleasant effects.

For pulmonary hypertension, take it as prescribed by your doctor.

Missed Dose

For erectile dysfunction, Penegra 100mg is taken as needed before sex. In that case, there is little chance of missing out on a dose.

If you forget to take a prescribed dose, take it as soon as you remember. If it is about time for your next scheduled dose, just leave out the missed dose. Then keep taking the next doses as usual.

Overdose

Penegra 100mg tablets need to be taken at the right dosage. Only then it can produce the desired results. Taking too much ED medication can lead to serious side effects. Talk to your doctor if there is an overdose.

Side Effects

Here are some possible side effects of Penegra 100mg tablets:

headache
heartburn
nausea
flushing
dizziness
diarrhea
nosebleeds
numbness
muscle pain
nasal congestion

In rare cases, sildenafil can lead to:

sudden loss of vision
blurred vision
loss of hearing
ringing in ears
chest pain
difficulty in breathing
painful erection that lasts longer than 4 hours

Safety Advice

Penegra tablets are generally safe when taken as prescribed.
Let your doctor know if you have the following:

heart disease
stroke
low blood pressure
liver or kidney problems
bleeding disorder
or any other conditions

Do not take Penegra if you’re intolerant to sildenafil. Or, if you are taking nitrates for chest pain or heart problems.
Learn about potential drug interactions including the ones listed above.
Call your doctor if any side effects bother you.
Penegra may make you feel drowsy or affect your vision. Do not drive or operate hazardous machinery under its influence.
Women should not use this medicine to improve sexual functions. However, sildenafil may be prescribed for men and women to treat pulmonary arterial hypertension.
100 mg is one of the highest doses available of sildenafil. Speak to your doctor before using the medicine for the first time.
Penegra 100mg should not be taken more than once a day.

Medical Interactions

Penegra 100mg tablets may interact with certain other medications. This may change the way this drug works and increase the risk of side effects. Tell your pharmacist or doctor if you are taking:

prescription drugs
over-the-counter (OTC) medications
vitamins
herbs or any other supplement

The following drugs tend to have more severe interactions with sildenafil:

nitrates (taken for chest pain)
alpha-blockers (treat high blood pressure or hypertension)
antifungals (such as itraconazole, ketoconazole)
blood thinners such as warfarin
barbiturates (treat improving sleep, reducing anxiety, muscle spasms)
beta-blockers such as atenolol or carvedilol
some antibiotics
HIV protease inhibitors (used to treat viral infections)
other ED medicines
medicines for seizures

Storage

Penegra 100mg tablets should be stored at room temperature.
The medicine should not be left in warm or humid places. Do not store it in the bathroom cabinet or near a sink. Heat, air, and steam can spoil the medicine.
Do not repack the medicine. Store it in the original packaging until you consume it.
Place the medicines in a locked cabinet where children and pets cannot reach.
Do not take medicines that have expired or those no longer needed. Even if you have bought it recently, check the label. If you’ve taken expired medicines by mistake, inform your doctor.
Discard any pills that have gone past their expiry date. Follow your local regulations and laws for their safe disposal.

Refrences

Fink HA, Mac Donald R, Rutks IR, Nelson DB, Wilt TJ. Sildenafil for male erectile dysfunction: a systematic review and meta-analysis. Arch Intern Med. 2002 Jun 24;162(12):1349-60. doi: 10.1001/archinte.162.12.1349. PMID: 12076233. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/211714
Loran OB, Ströberg P, Lee SW, Park NC, Kim SW, Tseng LJ, Collins S, Stecher VJ. Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt. J Sex Med. 2009 Oct;6(10):2826-35. doi: 10.1111/j.1743-6109.2009.01428.x. PMID: 19817982. https://www.jsm.jsexmed.org/article/S1743-6095(15)32273-6/fulltext
Smith BP, Babos M. Sildenafil. [Updated 2022 May 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558978/
Galiè N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, Fleming T, Parpia T, Burgess G, Branzi A, Grimminger F, Kurzyna M, Simonneau G; Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med. 2005 Nov 17;353(20):2148-57. doi: 10.1056/NEJMoa050010. Erratum in: N Engl J Med. 2006 Jun 1;354(22):2400-1. PMID: 16291984. https://www.nejm.org/doi/full/10.1056/NEJMoa050010
Sofikitis N, Kaltsas A, Dimitriadis F, Rassweiler J, Grivas N, Zachariou A, Kaponis A, Tsounapi P, Paterakis N, Karagiannis A, Skouros S, Giannakis I, Champilomatis I, Paschopoulos M, Daphnis D, Giakoumakis I, R Gabales M, M Chua JB, Lantin Iii PL, Mamoulakis C, Takenaka A. The Effect of PDE5 Inhibitors on the Male Reproductive Tract. Curr Pharm Des. 2021;27(23):2697-2713. doi: 10.2174/1381612826666200226121510. PMID: 32101115. https://www.eurekaselect.com/article/104866

Kim JN, Oh JJ, Park DS, Hong YK, Yu YD. Influence of Alcohol on Phosphodiesterase 5 inhibitors Use in Middle- to Old-Aged Men: A Comparative Study of Adverse Events. Sex Med. 2019 Dec;7(4):425-432. doi: 10.1016/j.esxm.2019.07.004. Epub 2019 Aug 20. PMID: 31444051; PMCID: PMC6963111. https://linkinghub.elsevier.com/retrieve/pii/S2050116119300935

Frequently asked questions (FAQs) about ED medication

How many Penegra 100mg tablets should I take for erection problems? Can I take Penegra every day?

For severe cases of erectile dysfunction (ED), a single dose of Penegra 100mg per day is typically sufficient. Do not take it daily without medical supervision. The dosage may be adjusted based on the patient’s response. Only a healthcare professional can determine the appropriate dosage. Do not exceed one dose in a 24-hour period.
How should I take Penegra 100mg for best results?

Penegra 100mg tablets should be taken orally, with or without food. Swallow the tablet whole; do not chew, split, or crush it. Avoid consuming large amounts of alcohol with this medicine and do not mix it with other medications.
Who should not take Penegra 100mg?

Penegra 100mg should be avoided by patients using nitrates (for angina or high blood pressure) or riociguat (for arterial hypertension). Certain medications can interact with Penegra 100mg, potentially leading to adverse effects. Refer to the “Drug Interactions” and “Safety Advice” sections for more details.
How does Penegra 100mg work?

Penegra 100mg works by improving blood flow to the penis during sexual arousal, which helps in achieving and maintaining a firm erection.